Chemoselective ligation is a powerful tool for conjugating biomolecules with various substrates. This chemistry can be applied to synthetic peptides and proteins for the following applications: attachment of delivery vectors (cell-penetrating peptides); fluorescent labelling for imaging; conjugating carrier proteins (e.g. KLH) for the production of antibodies; PEGylation for stabilising drugs; and, creating biofunctional surfaces. Modpep can employ various ligation reactions with synthetic peptides, including (but not limited to) disulfide and thioether bridges, maleimide-thiol chemistry, oxime ligations and alkyne-azide click reactions.
